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NTERILIZERĀ® provides products and protocols for the sterilization of Liquid Nitrogen in Assisted Reproduction (AR) clinics.

Every piece of equipment and all disposables used in the human In Vitro Fertilization (IVF) clinic is sterile, except Liquid Nitrogen. Studies have shown that Liquid Nitrogen can easily become contaminated. In 2003, Bielanski reported that 100% of the tanks examined were contaminated; this finding was confirmed by Morris in 2005.
Contamination creates a risk for the samples.
We offer an inexpensive and easy to implement method to sterilize Liquid Nitrogen in each of the three situations where contamination can occur: at preparation, during storage and at warming.

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NTERILIZER ha brevettato e intende commercializzare prodotti per la sterilizzazione di azoto liquido mediante radiazione ultravioletta. Si tratta di una tecnologia unica sul mercato, semplice e conveniente, adatta alle nuove e più severe regole per la Procreazione Medicalmente Assistita.

Sterilize Liquid Nitrogen for each situation


NTERILIZER provides an effective and easy to implement method to sterilize LNwith UV radiation for the procedure of vitrification


NTERILIZER offers a method to decontaminate cryotanks efficiently and effectively using UV radiation


NTERILIZER allows embryologists to clean cryocarriers stored in contaminated dewars

UV sterilizing technology

Ultraviolet (UV) radiation is widely used to sterilize water, air and surgical materials.

UV radiation is subdivided into UV-A (wavelength 315-400 nm), UV-B (280-315 nm), and UV-C (40-280 nm). UV-C is the most energetic portion of ultraviolet radiation; it can cause electronic excitation leading to the breaking of chemical bonds and the formation of unpaired electron species, known as radicals, that are highly reactive and can damage DNA and cell replication deactivating all kinds of microorganisms from viruses to fungi. The technology to generate UV-C is based on a bulb that contains gaseous mercury which, when subjected to electricity, emits an ultraviolet radiation, 95% of which is at 253.7 nanometers. This wavelength is in the region of maximum germicidal effectiveness and is highly lethal to virus, bacteria and mold spores.



Protocols to Sterilize the IVF Cold Chain

Vitrification of oocytes and embryos


Decontamination of carriers using sterile Liquid Nitrogen


Sterilization of empty dewars


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Via Castiglione 7 - Palazzo Pepoli Campogrande Scala C
40124 - Bologna - ITALY
Via M. D' Azeglio 57 - 40123 Bologna - ITALY
+39 - 0513547676
C.F. P.IVA 03656251208
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